
Polynucleotides have become extremely popular in aesthetics and regenerative medicine because of their powerful bioregenerative properties. But what exactly do they do, and why are they so effective in treatments that improve skin quality?
What are polynucleotides and how do they work?
Polynucleotides are DNA sequences. Their role in skin treatments is to promote bioregeneration, that is, the renewal of the skin at cellular level. As we age, the levels of hyaluronic acid, collagen and the skin's own polynucleotides decline, which results in a loss of elasticity and tone and the appearance of wrinkles. By introducing polynucleotides through treatment, we restore vitality, hydration and natural radiance to the skin.
Benefits of polynucleotide treatment
1. Stimulation of collagen synthesis: one of the key effects of polynucleotides is that they promote the production of collagen, the protein responsible for the elasticity and firmness of the skin. This process results in firmer, smoother skin with less pronounced wrinkles.
2. Improved skin texture and tone: as well as strengthening the skin, polynucleotides contribute to better hydration, making the skin softer, smoother and more even. They also reduce hyperpigmentation and scarring, particularly scarring caused by acne.
3. Anti-inflammatory action: these molecules are able to reduce inflammatory processes, which makes the treatment ideal for people with sensitive skin or with concerns such as redness and irritation.
How is the treatment performed?
Polynucleotides are injected directly into the skin, targeting the areas of concern. The procedure is minimally invasive and the first results are visible within a few days. Treatment is recommended once a month, with the best results achieved after three treatments spaced a few weeks apart.
Preparation and combination with other treatments
Before you begin polynucleotide treatment, deep cleansing of the skin is recommended, for example with treatments such as Derma Clear or HydraFacial. This preparatory step allows the polynucleotides to penetrate the skin better and deliver maximum effect.
Polynucleotide treatment is often combined with procedures such as Morpheus8 and Dermapen, which contributes to even better results in skin regeneration and rejuvenation.
Preparation and combination with other treatments
Polynucleotides are extremely safe for all skin types, and they are particularly well suited to those who want:
Improved skin tone and texture
Reduced hyperpigmentation
Treatment of acne scarring
Preparation of the skin for other aesthetic procedures such as Botox, lasers or fillers

Polynucleotides are also an ideal choice for anyone looking for an anti-ageing treatment that is both natural and effective.
As with any treatment, there are certain contraindications. Polynucleotides are not recommended for people with active inflammatory processes on the skin, such as herpes.
Polynucleotide treatments go a step further with innovative products such as Plinest and Newest. These preparations are the latest generation of polynucleotides, offering even more powerful bioregeneration and deep hydration of the skin. Plinest is particularly effective at restoring tone and elasticity, while Newest treats finer lines and evens out skin texture.
Try these outstanding treatments at Miren Clinic and experience the transformation of your skin. Our specialist team of dermatologists will create a treatment plan tailored to your needs. Book your appointment and refresh your skin with the power of polynucleotides. Call us on 064 951 0000.
Interested in polynucleotide treatment?
Find out more about the procedure, its indications, treatment areas and prices on the polynucleotide treatment in Belgrade page, or book a consultation with our specialist team straight away.


